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June 18, 2013
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Stem Cell Siblings


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Preimplantation Genetic Diagnosis: The Next Big Thing?

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"How Designer Children Will Work" - Howstuffworks.com



   09.09.04
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Reproductive medicine allows parents who've passed on a genetic disease once to ensure their next child is healthy— and while they're at it, make sure the new baby can save their sick child. This ScienCentral News video has more.

From One Sibling To Another

Lisa and Jack Nash were both carriers of a gene mutation that lead their first daughter to be born with a rare and devastating genetic disorder.

"Fanconi Anemia is a very rare genetic disease— there's only somewhere between five hundred and seven hundred cases in the world," says Lisa Nash. "Both my husband and I are carriers, we gave Molly a bad copy of the gene, so Molly got Fanconi Anemia."

Molly was born with numerous birth defects, one of them life-threatening, and she needed a bone marrow transplant. The Nash's could not find a match for Molly. Lisa and Jack also knew that they wanted to have more healthy children.

"So, having a sibling the old fashion way was not an option for us" Says Lisa Nash.





But preimplantation genetic diagnosis (PGD) was.





PGD is a technique that allows parents who are carriers of a genetic disease to have a healthy child by screening embryos for genetic diseases. It may help in preventing pregnancy terminations.




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"This technique gives us the opportunity to look at genetic disease in an embryo before we transfer the embryo back into the uterus," says Yury Verlinsky, fertility expert and director of the Reproductive Genetics Institute in Chicago. "This way we know in advance if the embryo is healthy or not healthy for a specific disease."

"This has never been done before in the world," says Nash. "We were the first family to do PGD for Fanconi Anemia, and to also have a baby that was healthy, and a bone marrow tissue type to match Molly."

Adam Nash wasn't just their newest child; he was also a donor for his sister Molly. He was born after doctors fertilized several of Lisa's eggs, but only implanted one that was both genetically healthy and a match as a donor. Blood from Adam's umbilical cord was used to cure Molly.

"This is the beauty of doing PGD; Adam was never touched in saving Molly's life and giving Molly a second chance at a healthy life," says Nash. "Adam's cord had been cut, my placenta had been delivered— the placenta which is usually garbage… They took this garbage, collected the cord blood, the placenta stem cells, and that's what Molly received as her transplant and her second chance on life."

The Nashes say that some have critized their decision, but they are thrilled with their family. Molly is now a healthy little girl who received the best gift any sister could get from their brother, life.

Verlinsky's research was published in the May 2005 issue of the Journal of the American Medical Association, and was funded by the Reproductive Genetics Institute.


 
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